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New research has linked popular GLP-1 weight loss drugs such as Ozempic and Wegovy to unexpectedly high rates of nail detachment, hair loss, and scalp inflammation, with weight loss alone not fully explaining the differences. Separately, ongoing lawsuits allege the drugs can cause serious harm like blindness or pancreatitis, but a lack of comprehensive adverse-event data makes it difficult to determine how often such harms occur. Together, the developments add to a growing body of scrutiny over the real-world safety profile of GLP-1 medications as their use becomes widespread.