Updated

Christina Applegate revealed on her podcast "MeSsy" on Tuesday, October 20, that she was misdiagnosed with multiple sclerosis, the disease she believed she had since 2021. She said a doctor told her "congratulations, you don't have MS," leaving her "back at square one" and unsure what is actually causing her ongoing symptoms. The actress returned to the podcast after a seven-month hiatus taken for health reasons, tearfully describing the revelation to cohost Jamie-Lynn Sigler as a "mindf—." The disclosure upends years of public discussion about her MS diagnosis and treatment.