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No. 9 Indiana beat No. 18 USC 27-13 on Saturday in Bloomington, Indiana, for its best win of the season, with fill-in quarterback Grant Wilson throwing for 305 yards and two touchdowns. Coach Curt Cignetti had decided to start Wilson, a seventh-year player who had not started since 2024 with Old Dominion, after replacing Josh Hoover in the second half against Minnesota. Hoover has been dealing with a throwing shoulder injury since Oct. 17. The offense played more aggressively than in recent weeks, recording its highest points total since Oct. 3 at Rutgers and averaging 17.9 yards per pass. Wilson connected with Nick Marsh for 65 yards and sealed the win with a 42-yard touchdown to Charlie Becker with 3:30 left. Cignetti said the team had been playing conservatively and wanted to attack, and linebacker Isaiah Jones intercepted a Jayden Maiava pass while Indiana led 20-13. ESPN reported that Cignetti will evaluate the starting quarterback position next week. USC coach Lincoln Riley blamed too many mistakes and dropped interceptions for the loss, the Trojans' third, which could end their hopes of a first CFP appearance, while Indiana moved closer to a third straight CFP trip under Cignetti.